Antibodies to nuclear enzymes - Clinical significance
1) Physiologic changes in the concentration of Antibodies to nuclear enzymes
2) Pathologic changes in the concentration Antibodies to nuclear enzymes a) Increased Antibodies to nuclear enzymes in: Dermatomyositis Polymyositis Fibrosing alveolitis Anti-synthetase syndrome
Material
Pattern: Jo-1
Substrate: Hep2-cells
Description
Fine to coarse decoration of nuclei with dust-like fluorescence of cytoplasm. (Pattern very variable dependent on brand of Hep 2-cells)
Method
Indirect immunoflourescence method.
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In children, ani- Jo-1 are extremly rare (196)
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More than 90% of the Caucasian patients with anti-Jo-1 have the HLA allele DR3 (195)
(ANCA)
