Introduction
Autoimmune diseases
Autoantibodies - Introduction
Autoantibodies - Determination
 
Autoantibodies
Rheumatoid Factor
Antinuclear Antibodies (ANA)
Specific Antibodies
Anti-neutrophil Cytoplasmic Antibodies
(ANCA)
Anti-phospholipid Antibodies
Anti-mitochondrial Antibodies (AMA)
Anti-endothelial Cell Antibodies (AECA)
Anti CCP antibodies
Antibodies against DNases
 
Quality Assurance
 
Reference ranges
 
Algorithm
ANA and incidence of diseases
Proposed stepwise diagnosis scheme
Positive Immunoflourescence -
Nucleoplasmic
Positive Immunoflourescence - Nucleolar
Positive Immunoflourescence -
Cytoplasmic
Type of autoimmune diseases
Conditions associated with antinuclear
antibodies (ANA)
 
Slide show
 
References
 
Collaborators
Rheumatoid Factor - Interferences


Preanalytical and analytical influences on test Increased
Mercury exposure
Aging in older nonsmokers (in serum positive)
Health 2-10% (in serum positive)
Smoking - in young smokers (in serum positive)
Lipemia
Cryoglobulines
Circulating immune complexe
Multiple vacctiations and transfusions have been administered

 

Drug interference

Biological

Decreased values:

 

Increased values:

Methyldopa

Analytical

Decreased values:

 

Increased values:

 


Methyldopa (aldomet) is an antihypertensive drug

Mol. Weight             211.2
Therapeutic conc.    1-7.5 mg/L
Toxic conc                 10 mg/L
Elimination Halflife  1.3 hrs

Reference range

Reference values
dependent on method

Agglutation

negative (<1:20)

Nephelometry

< 40 U/L

ELISA

 

IgM RF

IgA RF

IgG RF

Units

Negative

< 16

< 20

< 30

U/ml

Equivocal

16-24

20-30

30-40

U/ml

Positive

> 24

> 30

> 40

U/ml