1) Physiologic changes in the concentration of Anti-phospholipid Antibodies
2) Pathologic changes in the concentration Anti-phospholipid Antibodies
a) Increased Anti-phospholipid Antibodies in:
  SLE
Primary antiphospholipid syndrome (APS)
Rheumatic and non-rheumatic diseases
Hematological, myeloproliferative, and lymphomatous disease
myocardial infarction
Addison’s disease
Drug-induced lupus syndromes
many viral diseases
Reference values
dependent on method |
Immunofluorescence method. |
negative |
ELISA |
|
negative |
Low positive |
Moderate positive |
High positive |
Units |
IgG |
< 20 |
20 –30 |
31 – 50 |
> 51 |
GPLU/ml |
IgM |
< 1.5 |
1.5 –2.5 |
2 – 9.9 |
> 10 |
MPL /ml |
IgA |
< 10 |
10 -20 |
21 – 30 |
> 31 |
arb U/ml |
Indication
- suspected SLE
-
prenatal pregnancy monitoring in patients with SLE
-
recurrent abortions
-
thromboembolic events of undetermined origin
-
evaluation of a prolonged APTT
|
