1) Physiologic changes in the concentration of p-ANCA
2) Pathologic changes in the concentration p-ANCA
 a) Increased p-ANCA in:
 Microscopic polyarteritis
Polyangiitis
Panarteritis nodosa
Chronic polyarthritis
Churg-Strauss syndrome
Goodpasture’s syndrome
Hydralazine-induced lupus erythematosus
Myelitis
Irritable bowel syndrome
Primary sclerosing cholangitis
Reference values
dependent on method |
Immunofluorescence method. |
negative |
ELISA |
|
|
Units |
negative |
< 5 |
U/ml |
positive |
> 5 |
U/ml |
 |
Material
Pattern: pANCA
Substrate: Formalin fixed
Description
Evenly distributed granular fluorescence in the cytoplasm
Method
Indirect immunoflourescence method. |
pANCA (perinuclear ANCA) is more heterogeneous. In may be directed against myeloperoxidase (as seen most typically but not exclusively in microscopic polyangiitis), lactoferrin,elastese, cathepsin G and other antigens.
pANCA are defined as antibodies staining the perinuclear cytoplasm or the nucleus.
|
