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Creatinine

Clinical significance

In serum In urine
1) Physiologic changes in serum creatinine concentration 2) Pathologic changes in serum creatinine concentration 1)Physiologic changes in urine creatinine concentration 2) Pathologic changes in urine creatinine concentration
After ingestion creatine (e.g. roast meats)A) Increased serum creatinine concentration in:
• acquired hemolytic anemia (autoimmune),
• acute and chronic leukemia,
• acute and chronic myelocytic leukemia,
• acute myocardial infarction,
• acute pancreatitis,
• acute poststreptococcal glomerulonephritis,
• acute pyelonephritis,
• acute renal failure ,
• amyloidosis,
• arterial embolism and thrombosis,
• bacterial endocarditis,
• benign prostatic hypertrophy,
• bladder carcinoma,
• cancer of colon,
• cancer of prostate,
• cancer of testis,
• cancer of uterus,
• cholangitis,
• chronic renal failure,
• congestive heart failure ,
• cystinosis,
• diabetes mellitus,
• eclampsia,
• essential hypertension,
• glomerulonephritis, membranoproliferative,
• gout,
• hepatic failure,
• hepatolenticular degeneration,
• herpes zoster infection,
• Hodgkin’s disease,
• hydronephrosis,
• hyperparathyroidism,
• hypothyroidism,
• IgA nephropathy,
• leptospirosis,
• malaria,
• multiple myeloma,
• nephrotic syndrome,
• polycystic kidney disease,
• pre-eclampsia,
• progressive glomerulonephritis,
• progressive systemic sclerosis,
• psittacosis,
• renal artery embolisms,
• Reye’s syndrome,
• sarcoidosis,
• sepsis,
• septic shock,
• septicemia,
• shock,
• SLE,
• urethritis,
• vomiting.
B)Decreased serum creatinine concentration in:
• anorexia nervosa,
• eclampsia,
• hyperthyroidism
• liver cirrhosis,
• pre-eclampsia
Daily creatinine excretion in urine is constant and proportional to total muscle mass. Urinary excretion of creatinine increases upon intake of creatinine rich food (e.g., roasted meat).A) Increased urine creatinine concentration in:
• acromegaly,
• gigantism,
• hypothyroidism,
• infection,
• renovascular hypertension.
B)Decreased urine creatinine concentration in:
• active dermatomyositis,
• advanced renal disease, before the final stage of failure,
• Alzheimer-Type Dementis,
• amyotrophic lateral sclerosis,
• anemia,
• hyperthyroidism,
• leukemia, returning towards normal in remission,
• muscular dystrophy,
• myotonia atrophica,
• paralysis,
• pre-eclampsia,
• progressive muscular dystrophy,
• protein malnutrition.