The secretion of active substances is a non-specific passive process, and it is a consequence of irreversible alterations, i.e., disintegration of thrombocytes. So far the very process of secreting of active substances has not been shown yet successfully.
It has been confirmed that thrombocytes may be induced to secreting substances by collagen, ADP, biologically active amines (serotonin, adrenaline, noradrenaline, histamine), proteolytic enzymes (thrombin, trypsin, reptilase), warm aggregated gamma globulin, latex particles, kaolin particles, bacterial endotoxins, antigen-antibody complexes, and uric acid crystals. This statement is very important for understanding of the pathological blood coagulation and for illuminating the mechanism of coagulation, as well as to coagulation (thrombosis) without a previous damage to the vessel wall.
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